Otosporin Eardrop (Polymyxin B) uses to treat and prevent an infection caused by the bacteria that is also known as Swimmer’s ear. The medicine contains polymyxin and neomycin that are antibiotics and works by stopping the growth of bacteria. This medicine also contains hydrocortisone that is an inflammatory corticosteroid, and it’s an agent that reduces the swelling of the ear and discomfort. This medicine is indicated to treat otitis externa that is caused by any bacterial infection.